The Collapse of Monolayers Containing Pulmonary Surfactant Phospholipids Is Kinetically Determined
نویسندگان
چکیده
منابع مشابه
Pulmonary surfactant is a complex of phospholipids
This article is available online at http://www.jlr.org Pulmonary surfactant is a complex of phospholipids ( 90%) and proteins ( 10%) that reduces the surface tension in the alveoli of the lung ( 1, 2 ). Pulmonary surfactant is crucial for normal breathing and its defi ciency leads to fatal respiratory distress syndromes ( 3 ). The major phospholipids in pulmonary surfactant are phosphatidylcho...
متن کاملPulmonary surfactant is a mixture of phospholipids
(80–90%), neutral lipids (10%) and proteins, and is secreted into the alveolar airspace to reduce and vary surface tension in response to changes in lung volume (King, 1982). The most abundant phospholipid (PL) is phosphatidylcholine (PC) (79–85%) (King, 1982), and its disaturated form, dipalmitoylphosphatidylcholine (DPPC), containing two molecules of the fatty acid, palmitate, is the major co...
متن کاملThe melting of pulmonary surfactant monolayers.
Monomolecular films of phospholipids in the liquid-expanded (LE) phase after supercompression to high surface pressures (pi), well above the equilibrium surface pressure (pi(e)) at which fluid films collapse from the interface to form a three-dimensional bulk phase, and in the tilted-condensed (TC) phase both replicate the resistance to collapse that is characteristic of alveolar films in the l...
متن کاملPulmonary surfactant protein A interacts with gel-like regions in monolayers of pulmonary surfactant lipid extract.
Epifluorescence microscopy was used to investigate the interaction of pulmonary surfactant protein A (SP-A) with spread monolayers of porcine surfactant lipid extract (PSLE) containing 1 mol % fluorescent probe (NBD-PC) spread on a saline subphase (145 mM NaCl, 5 mM Tris-HCl, pH 6.9) containing 0, 0.13, or 0.16 microg/ml SP-A and 0, 1.64, or 5 mM CaCl(2). In the absence of SP-A, no differences ...
متن کاملRapid compression transforms interfacial monolayers of pulmonary surfactant.
Films of pulmonary surfactant in the lung are metastable at surface pressures well above the equilibrium spreading pressure of 45 mN/m but commonly collapse at that pressure when compressed in vitro. The studies reported here determined the effect of compression rate on the ability of monolayers containing extracted calf surfactant at 37 degrees C to maintain very high surface pressures on the ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2005
ISSN: 0006-3495
DOI: 10.1529/biophysj.105.060947